Traumatic Brain Injury (TBI)
Trans-Ocular Bioimpedance: Seeing the Brain through the Eyes (TOBI)
A wearable device that uses electrical bioimpedance and ultrasound to not only evaluate intracranial pressure (ICP) but also monitor cerebrovascular autoregulation (CAR) to help inform the diagnosis and treatment of TBI.
TOBI is non-invasive, does not require an experienced operator, and is compact in size, meaning it can be used by caregivers across all echelons of care.
This work is supported by the Office of the Assistant Secretary of Defense for Health Affairs through the JPC-6 Combat Casualty Care / Defense Medical Research and Development Program under an assistance agreement from the U.S. Army Medical Research Activity, Award No. W81XWH-18-1-0005.
Team:
Hakam Tiba, MD, MS (PI)
Kevin Ward, MD (Co-I)
Brendan McCracken, MS (Project Manager)
Diagnostic Tool for Coagulation Abnormalities in TBI
A point-of-care microfluidic viscometer that assesses the coagulation process in whole blood by measuring changes in viscosity. The device works by flowing blood and oil into a cross section where droplets are produced. Here, the length of the droplets is inversely proportional to the viscosity of the blood sample.
This diagnostic tool is less expensive and simpler to use than current benchtop equipment. It allows for higher frequency bedside measurements than are currently possible and can also be leveraged to reduce complications associated with polytrauma and transfusion therapy.
Team:
Mark Burns, PhD (PI)
Kevin Ward, MD (Co-I)
Brendan McCracken, MS
Intracranial Pressure Monitor Enhancement For Cerebral Hemodynamic Monitoring
Enhancing an existing intracranial pressure (ICP) monitor with miniature piezoelectric pressure and optical blood volume sensors that provide synchronized, high-bandwidth measurements of heartbeat-to-heartbeat local pressure and blood volume fluctuations.
The modified ICP monitoring catheter will be nearly identical after modification to its existing form factor and, without altering the standard TBI workflow, will enable monitoring of blood flow in the region of the ICP monitor in addition to the monitor’s standard pressure measurement.
Team:
Kenn Oldham, PhD (PI)
Hakam Tiba, MD, MS (Co-I)
Craig Williamson, MD (Co-I)
Kevin Ward, MD (Co-I)
Brendan McCracken, MS
Lu Wang, PhD
Sensor technology that utilizes nanoporous gold electrodes integrated into a microfluidic device, to directly measure redox in whole blood at the patient’s bedside. The ability to directly and rapidly measure redox could help guide therapeutic interventions in a variety of patients.
By providing information to clinicians related to responsive drug delivery and responsiveness to resuscitation efforts, the Redox Point-of-Care Device can improve outcomes and reduce costs in TBI, Sepsis and other diseases
Team:
Rodney Daniels, MD (PI)
Hakam Tiba, MD, MS (Co-I)
Brendan McCracken, MS