Grants

Active Grants

Development and Validation of a Clinically Relevant Swine Model ofNeurologic Injury After Cardiac Arrest to Translate Neuroprotecti Therapies 

The aim of this project is to establish a feasible, lower-cost, and clinically relevant swine cardiac arrest model with quantitative pharmacodynamics biomarkers of post-cardiac arrest brain injury that can be used to validate neuroprotective therapies, which will catalyze translation to clinical trials.

Name of PD/PI:  Hsu, Cindy

Source of Support: NIH/NINDS 

Project Dates: 07/01/2022 - 06/30/2025 

Total Award Amount: $1,154,294.00 

Development of an Ultrasound-based Flow-pressure Index for the Assessment of Cerebral Autoregulation 

The aim of this project is to develop a novel flow/pressure index to assess cerebrovascular autoregulation post TBI.


Name of PD/PI:  Hakam Tiba and Brian Fowlkes


Source of Support:  Massey Family Foundation 


Project Dates:  07/01/2023-6/30/2024 


Total Award Amount: $142,980 


Detection of Exhaled Breath Markers After Traumatic Brain Injury using Point of Care Gas Chromatography 

To identify compounds that show dynamic changes post-TBI as opposed to preinjury levels and how these compounds relate to metrics such as ICP and blood markers.

Name of PD/PI: Tiba, Hakam

Source of Support: The University of Michigan Medical School Office of Research

Project Dates:  07/26/2023-07/26/2025 

Total Award Amount:  $80,000

Past Grants

TRANSatlantic Cardiac arrEst Neuroprotection aDvancement (TRANSCEND) Network Preclinical Registry:
Consultant on (Principal Investigator:Robert Neumar)
Laerdal Foundation
06/2022 - 08/2023
$42,000

 

Impact of mask application on aerosol generation during CPR in a swine cardiac arrest model:
Co-I (Principal Investigator:Cindy Hsu)
Zoll Foundation
07/2021 - 12/2023
$73,818

 

Hemodynamic benefits of aortic balloon occlusion during left ventricular assist device (Impella) CPR:
PI
Abiomed Inc
06/2021 - 10/2022
$174,740

 

Device to Aid in Arterial Microanastomosis:
Co-I
Baxter Healthcare Corporation
11/2019 - 11/2021
$156,952

 

Michigan Resuscitation Innovation and Science Enterprise (M-RISE):
Co-I
AHA
07/2019 - 06/2023
$645,248

 

Michigan Resuscitation Innovation and Science Enterprise (M-RISE):
Co-I
AHA
07/2019 - 06/2023
$687,205

 

Michigan Resuscitation Innovation and Science Enterprise (M-RISE):
Co-I
AHA
07/2019 - 06/2023
$1,581,392

 

ART-123 (recombinant human thrombomodulin alpha) in prolonged porcine cardiac arrest:
Co-I (Principal Investigator:Colin Greineder)
Asahi Kasei Pharma Corporation
07/2019 - 03/2021
$35,988

 

ART-123 (recombinant human thrombomodulin alpha) in porcine cardiac arrest:
Consultant on (Principal Investigator:Colin Greineder)
Zoll Foundation
01/2019 - 12/2020
$47,773

 

Development and Testing of New Noninvasive Monitoring Tools for Prolonged Field Care Goal Directed Therapy:
Co-I (Principal Investigator:Kevin Ward)
Army-DoD-US
04/2018 - 03/2022
$2,998,209

 

Gastroesophageal Resuscitative Occlusion of the Aorta (GROA):
Co-I (Principal Investigator:Kevin Ward)
Army-DoD-US
02/2018 - 01/2022
$2,995,616

 

Novel Noninvasive Methods of Intracranial Pressure and Cerebrovascular Autoregulation Assessment: Seeing the Brain through the Eyes:
PI
Army-DoD-US
01/2018 - 12/2021
$1,480,171

 

R01HL133129:ECPR After Prolonged Cardiac Arrest: Targeting Mechanisms of the No-Reflow:
Co-I
NIH-DHHS-US
07/2017 - 06/2022
$3,067,247

 

Comparison of Respiratory Induced Limb Bioimpedance Changes with Inferior Vena Cava Diameter Changes to Assess Intravascular Volume Status in Patients Undergoing Hemodialysis:
Co-I (Principal Investigator:Michael Heung)
RRI
06/2015 - 05/2017
$42,830

 

Comparison of Respiratory Induced Limb Bioimpedance Changes with Inferior Vena Cava Diameter Changes to Assess Intravascular Volume Status:
MPI
Kevin Ward(MPI);Mohamad Hakam Tiba(MPI)
Baxter Healthcare Corporation
12/2014 - 08/2015
$154,654

 

Multi-laboratory Study of Epinephrine in Experimental Cardiac Arrest:
MPI
Mohamad Hakam Tiba(MPI);Robert Neumar(MPI)
St. Michaels Hospital
11/2013 - 12/2015
$10,000