Current Projects

Sepsis: 


Sepsis is a severe inflammatory response to infection that can lead to multiple organ failure, resulting in permanent disability or death. Our research aims to enhance the pathophysiologic understanding of inflammation to develop new technologies for ultra-early diagnosis and therapeutic guidance. Although the incidence of multiple organ failure has decreased over time, it remains morbid, lethal and resource intensive. Single organ dysfunction—especially acute lung injury—however, remains frequent. 


Publication

https://doi.org/10.1371/journal.pone.0243577 


Acute Respiratory Distress Syndrome (ARDS)


The acute respiratory distress syndrome (ARDS) is a life-threatening lung condition that affects more than 200,000 people in the United States each year with a mortality rate of approximately 40%. As a clinically defined syndrome, ARDS has undergone only modest refinement in its definition since its first report in 1967. Despite a half century of experimental and clinical study, the diagnosis of ARDS remains entirely clinical (with no molecular biomarkers), and its management remains entirely supportive (with no targeted therapies). 


For further information New preclinical research models could lead to better diagnosis, treatment of sepsis and ARDS — The Max Harry Weil Institute for Critical Care Research and Innovation (umich.edu) 


Publication 

https://doi.org/10.14814/phy2.14871 

10.1183/23120541.00154-2021

Traumatic Brain Injury (TBI)

Traumatic Brain Injury (TBI) is a major source of mortality and morbidity. Based on the most recent data, there were approximately 200K TBI-related hospitalizations in 2019 and 70K TBI-related deaths in 2021. This represents more than 611 TBI-related hospitalizations and 190 TBI-related deaths per day. If the patient survives the TBI, there can be long term costs requirement for care caused by the permanent brain damage. Not everyone who suffers trauma to the head has significant TBI, but both diagnosis and distinguishing TBI severity can be very challenging. 


Projects 


Publication 

Cardiac arrest and CPR Optimization


Cardiac arrest remains a major public health challenge with an estimated global incidence of 55/100,000 person-years for out-of-hospital cardiac arrest (OHCA). In the United States, close to 600,000 patients are treated for OHCA and in-hospital cardiac arrest (IHCA) each year. with fewer than 10% of OHCA and 24% of IHCA patients surviving hospital discharge. The majority of OHCA patients do not achieve a return of spontaneous circulation (ROSC) despite current advances in cardiovascular life support and resuscitative efforts. We aim to use preclinical models to optimize CPR, ROSC and survival with intact neurological function.


Projects


Related Publications

Hemorrhage Control and Hemostasis Devices

Hemorrhage from potentially survivable injuries is estimated to be responsible for more than 90% of military combat casualties and 40% of civilian trauma deaths. Despite recent advancements in hemorrhage management, such as the treatment of extremity and junctional hemorrhage, treatment of noncompressible torso hemorrhage (NCTH) continues to pose almost intractable challenges, especially in the prehospital setting where almost 9 of 10 deaths occur. We aim to develop hemostasis modality to control NCTH until patients reach a a higher level of care.


Projects


Related Publications