Preclinical Models
ARDS
Acute respiratory distress syndrome (ARDS) is a life-threatening lung injury that allows fluid to leak into the lungs. Breathing becomes difficult and oxygen cannot get into the body. Most people who get ARDS are already at the hospital for trauma or illness. (lung.org)
Our Capabilities
Model of a combination of indirect injury (as in sepsis model) and direct lung injury using
volutrauma
hyperoxia (100% fiO2)
gastric asperation
Measurements of hemodynamics and sequential measurements of blood gases, electrolytes, CBC, liver and kidney function
Sampling for microbiome and metabolomics studies
Long-term monitoring and care for up to 24 hours in an ICU setting
Monitoring ventilation
X-rays, radiographic imaging
Tissue sampling for histology
Cardiac Arrest
Cardiac arrest occurs when the heart’s electrical system malfunctions. The heart stops beating properly. The heart’s pumping function is “arrested,” or stopped. More than 356,000 cardiac arrests occur outside a hospital in the U.S. each year. (heart.org)
Our Capabilities
Model of induced ventricular fibrillation, mechanical ventillation, manual ventillation, and long-term monitoring
SSEP
Transesophageal Echo (TEE)
Long-term monitoring in an ICU setting
Aortic occlusion
Neuroprotective Therapies
Goal-directed CPR
Hemorrhage Control
Trauma is the leading cause of death in the U.S. between the ages of 1 and 46, accounting for 41 million ER visits each year. On the battlefield, approximately 80% of all deaths occur within the first 30 minutes of wounding.
Our Capabilities
Model of controlled systemic hemorrhage, or uncontrolled organ-specific or vascular injuries
Continuous measurement of oxygen debt during hemorrhage and resuscitation
Long-term monitoring post-resuscitation
Sepsis
Sepsis is the body’s overwhelming and life-threatening response to infection which can lead to tissue damage, organ failure, and death. Sepsis kills approximately 270,000 Americans each year. (Sepsis.org).
Our Capabilities
Model of severe urinary tract infection through direct innoculation into the kidney parenchyma using e. coli
Measurements of hemodynamics and sequential measurements of blood gases, electrolytes, CBC, liver and kidney function
Sampling for microbiome and metabolomics studies
Long-term monitoring and care for up to 24 hours in an ICU setting
Monitoring ventilation
Traumatic Brain Injury
Each year in the United States, an estimated 1.7 million people sustain a traumatic brain injury, 795,000 suffer a stroke, and 17,000 sustain a spinal cord injury.
Our Capabilities
Measuring arterial blood pressure, intracranial blood pressure, cerebral microcirculatory blood flow using laser Doppler, macrocirculatory blood flow using trans-cranial Doppler (middle cerebral artery)
Provocative maneuvers to perturb blood flow, such as epidural hematoma, vasopressor challenge, systemic hemorrhage and resuscitation
Direct cortical (blunt) impact using computerized impacter
Placement of intraventricular device in the lateral ventricle for collection of cerebrospinal fluid (CSF) and for measurement of intracranial pressure
"The Tiba Research Laboratory has enabled the study of the metabolic changes that occur during the development and progression of systemic infection. The preliminary data generated from this unique model supported an NIH grant application that was recently awarded."
Kathleen Stringer, PHARMD
Albert B. Prescott Professor, Clinical Pharmacy, University of Michigan